Phenylsulfonamide-phenylethylamines useful as dopamine receptors

Details Phenylsulfonamide-phenylethylamines useful as dopamine receptors Phenylsulfonamide-phenylethylamines useful as dopamine receptors

1999-05-07

2000-08-15

O'Sullivan, Peter

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Nitrogen containing other than solely as a nitrogen in an...

514524, 514602, 514603, 514810, 514812, 514923, 558413, 564 85, 564 86, 564 89, 564 92, A61K 31275, A61K 3118, A61K 31165

Patent

active

061037664

ABSTRACT:
Compounds of Formula I and their pharmaceutically acceptable salts having selective dopamine D3 receptor activity suitable for treating central nervous system disorders. Formula I: ##STR1## R.sub.1 is independently H or a C.sub.1 -C.sub.8 alkyl including isomeric forms thereof;

REFERENCES:
patent: 3574741 (1971-04-01), Gould
Ice, R.D., et al., "Concentration of Dopamine Analogs in the Adrenal Medulla," J. of Nuclear Medicine 16(12):1147-1151 [1975].
Kato, H. et al., "1-(Substituted aryl) alkyl-1H-imidazopyridin-4-amines as interferon inducers," CA 130-291590, [Mar. 26, 1999].
Baxter, E.W. et al., "Arylsulfonate Esters in Solid Phase Organic Synthesis. II. Compatibility with Commonly-Used Reaction Conditions," Tetrahedron Letters 39:979-982 [1998].
Sokoloff, P., et al., "Molecular cloning and characterization of a novel dopamine receptor (D.sub.3) as a target for neuroleptics," Nature 347:146-151 [1990].

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