Phenylsubstituted 4-azasteroid fluoroderivatives

Details Phenylsubstituted 4-azasteroid fluoroderivatives Phenylsubstituted 4-azasteroid fluoroderivatives

1999-04-28

2000-09-05

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3158

Patent

active

061143456

ABSTRACT:
Compounds of formula (I), wherein: the symbol ---- represents a single or a double bond; R is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; R.sub.f and R'.sub.f, each independently, are C.sub.1 -C.sub.4 alkyl groups substituted by one or more fluorine atoms; and R.sub.1 and R.sub.2, each independently, are selected from: a hydrogen atom; a phenyl group; a C.sub.1 -C.sub.4 alkyl group unsubstituted or substituted by one or more fluorine atoms; a halogen atom; a cyano (CN) group; a group OR.sub.4, wherein R.sub.4 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; a group SR.sub.5, wherein R.sub.5 is a hydrogen atom or a C.sub.1 -C.sub.4 alkyl group; and a group COR.sub.6, wherein R.sub.6 is a group OR.sub.4 in which R.sub.4 is as defined above or a C.sub.1 -C.sub.4 alkyl group unsubstituted or substituted by one or more fluorine atoms. They are useful as testosterone 5a-reductase inhibitors.

REFERENCES:
patent: 5155107 (1992-10-01), Panzeri et al.
patent: 5407939 (1995-04-01), Panzeri et al.
patent: 5418238 (1995-05-01), Panzeri et al.
George, "Androgen Metabolism in the Prostate of the Finasteride-Treated, Adult Rat," Endocrinology, vol. 138, No. 3, pp. 871-877, Mar. 1997.
Gormley et al., "The Effect of Finasteride in Men with Benign Prostatic Hyperplasia," The New England Journal of Medicine, vol. 327, No. 17, pp. 1185-1191, Oct. 1992.
Panzeri et al "Novel Aromatase and 5alpha-Reductase Inhibitors," J. Steroid Biochem. Molecular Biol., vol. 49, No. 4-6, pp. 289-294, 1994.
Giudici et al., "ECE 28260, a New 5-alpha-Reductase Inhibitor: In Vitro and In Vivo Effects," J. Steroid Biochem. Molec. Biol., vol. 58, No. 3, pp. 299-305, 1996.
di Salle et al., "PNU 157706, a Novel Dual type 1 and II 5-alpha-reductase inhibitor," J. Steroid Biochem. Miolec., vol. 64, No. 3-4, pp. 179-186, 1998.

Affiliated with

Also associated with

Rating

Phenylsubstituted 4-azasteroid fluoroderivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylsubstituted 4-azasteroid fluoroderivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylsubstituted 4-azasteroid fluoroderivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2212429