Phenylserine derivatives and processes for preparing the same

Details Phenylserine derivatives and processes for preparing the same Phenylserine derivatives and processes for preparing the same

1984-12-19

1987-09-22

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514414, 514415, 514416, 514422, 514423, 540520, 544162, 544391, 546146, 546226, 546309, 548251, 548452, 548455, 548465, 548467, 548482, 548517, 548518, 548525, 548526, 548527, 548533, 548536, 548540, 560 27, 560 29, 560 39, 562448, 564165, A61K 3140, A61K 31165, A61K 31215, C07D20908, C07D20944, C07D29518

Patent

active

046955801

ABSTRACT:
Novel phenylserine derivatives of the formula: ##STR1## and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions, and a process for preparing the compounds are disclosed. The phenylserine derivatives and pharmaceutically acceptable acid addition salts are capable of inhibiting the biosynthesis of leucotrienes and/or antagonistic activity against SRS-A and hence are useful for prophylaxis and treatment of various allergic diseases (e.g. bronchial asthma, allergic nasitis, urticaria), ischemic heart diseases, ischemic encephalopathy, inflammation, or the like.

REFERENCES:
patent: 2654754 (1953-10-01), Bruce et al.
patent: 2851494 (1958-09-01), Ehrhart et al.
patent: 4330558 (1982-05-01), Suzuki et al.
patent: 4497826 (1985-02-01), Narabayashi et al.
Helv. Chim. Acta., 1975, vol. 58, pp. 147-162, Hegedus et al.

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