Phenylpropyl-2,3-dihydrobenzofurans useful as anti-inflammatory

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514253, 514307, 514314, 514337, 514359, 514361, 514362, 514363, 514367, 514374, 514382, 514383, 514397, 514414, 514422, 514443, 514444, 514456, 514459, 514460, 514470, 544376, 546146, 546149, 546152, 546168, 546269, 548125, 548126, 548146, 548159, 548252, 548256, 548262, 548336, 548454, 548525, 549405, 549408, 549462, 549466, 549467, 549468, 549469, 549470, 549 57, 549 58, 549 60, A61K 3134, C07D30779

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047133937

ABSTRACT:
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.

REFERENCES:
patent: 3476771 (1969-11-01), Murahami et al.
patent: 4100294 (1978-07-01), Crague et al.
patent: 4189496 (1980-02-01), Crague et al.
patent: 4435422 (1984-03-01), Lee et al.
patent: 4490531 (1984-12-01), Johnson et al.
patent: 4495357 (1985-01-01), Johnson et al.
patent: 4537903 (1985-08-01), Chang et al.
patent: 4551468 (1985-11-01), Cross et al.
Asakawa et al., Phytochem., vol. 21(10), pp. 2481-2490, (1982).
Kostanecki et al., Berichte, pp. 3660-3669, vol. 40, (1907).
Starkov et al., Chem. Abstracts, vol. 79, 91907, (1973).
Merlini et al., J.C.S. Perkin I, pp. 1570-1576, (1976).
Marschalk, Berichte, vol. 42, pp. 4485-4487, (1909).

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