Phenylpiperazines

Details Phenylpiperazines Phenylpiperazines

2006-06-27

2006-06-27

Bernhardt, Emily (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S230500, C514S253060, C514S253070, C514S212070, C514S217050, C514S254020, C514S254060, C514S254090, C514S254110, C540S523000, C540S593000, C544S052000, C544S105000, C544S363000, C544S368000, C544S373000, C544S370000, C544S376000, C544S051000, C544S377000

Reexamination Certificate

active

07067513

ABSTRACT:
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as aggression, anxiety disorders, autism, vertigo, depression, disturbances of cognition, disturbances of memory, Parkinson's disease, schizophrenia, and psychotic disorders.The invention relates to a group of novel phenylpiperazine derivatives of the formula (I):wherein:X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text,m has the value 2 to 6;n has the value 0–2;R5and R6are independently H or alkyl (1–3C); or R5+R6represent a group —(CH2)—pwherein p has the value 3–5, andR7is alkyl (1–3C), alkoxy (1–3C), halogen or cyano; or R6+R7(R7at position 7 of the indole group) represent a group —(CH2)qwherein q has the value 2–4,and salts thereof.

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