Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2008-10-27
2009-10-20
Bernhardt, Emily (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S254060, C544S366000, C544S368000, C544S370000, C544S371000
Reexamination Certificate
active
07605162
ABSTRACT:
The invention relates to a novel group of phenylpiperazines having interesting pharmacological properties such as a high affinity for the dopamine D2receptor and/or the serotonin reuptake site, and the ability to treat conditions related to disturbances in the dopaminergic and/or the serotonergic systems such as anxiety disorders, depression, Parkinson's disease, and schizophrenia.The invention relates to a group of novel phenylpiperazine derivatives of the formula (I):wherein:X is a group of formula 1, 2, 3, 4, 5, 6, or 7 as defined in the text,m has the value 2 to 6;n has the value 0-2;R5and R6are independently H or alkyl (1-3C); or R5+R6represent a group —(CH2)—pwherein p has the value 3-5, andR7is alkyl (1-3C), alkoxy (1-3C), halogen or cyano; or R6+R7(R7at position 7 of the indole group) represent a group —(CH2)qwherein q has the value 2-4,and salts thereof.
REFERENCES:
patent: 6828325 (2004-12-01), Feenstra et al.
patent: 0 900 792 (1999-03-01), None
patent: 99/05140 (1999-02-01), None
patent: WO 99 67237 (1999-12-01), None
patent: WO 00 23441 (2000-04-01), None
patent: WO 01/14330 (2001-03-01), None
patent: WO 03/068207 (2003-08-01), None
Ribichaud et al., Chapter 2. Recent Advances in Selective Serotonin Receptor Modulation,Annual Reports in Medicinal Chemistry, vol. 35, pp. 11-20 (2000).
TenBrink et al., Chapter 5. Recent Advances in Dopamine D3 and D4 Receptor Ligands and Pharmacology,Annual Reports in Medicinal Chemistry, vol. 29, pp. 43-51 (1994).
Kruse Cornelis G.
Tipker Jacobus
Tulp Martinus T. M.
Van der Heijden Johannes A. M.
Van Hes Roelof
Bernhardt Emily
Finnegan Henderson Farabow Garrett & Dunner LLP
Solvay Pharmaceuticals
LandOfFree
Phenylpiperazine does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenylpiperazine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylpiperazine will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4120320