Phenyloxyaniline derivatives

Details Phenyloxyaniline derivatives Phenyloxyaniline derivatives

2005-03-22

2005-03-22

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S218000, C564S219000, C514S628000, C514S630000

Reexamination Certificate

active

06870069

ABSTRACT:
A phenyloxyaniline derivative useful as a ligand for peripheral benzodiazepine receptor having a strong affinity and a high selectivity, which is represented by formula (1):wherein X1and X2are same or different and each is hydrogen atom or halogen atom; R1and R2are same or different and each is hydrogen atom, an alkyl group having 1 to 10 carbon(s) or a halogen-substituted alkyl group having 1 to 10 carbon(s); and R3is a halogen-substituted alkyl group having 1 to 5 carbon(s), or a radioisotope thereof.

REFERENCES:
patent: 6333358 (2001-12-01), Nakazato et al.
patent: 11-171844 (1999-06-01), None
Zhang et al, Bioorganic & Medicinal Chemistry Letters, 13 (2003) 201-204.*
Zhang et al, “Radiosynthesis and Evaluation PET Tracers for Peripheral Benzodiazephine Receptor (PBR)” 22nd Symposium on Medicinal Chemistry (11thAnnual Meeting of Division of Medicinal Chemistry (Nov. 5, 2002).

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