Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyc

Details Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyc Phenyloxazolidinones having a c-c bond to 4-8 membered heterocyc

1999-02-10

2000-04-18

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546209, 5462714, C07D41304

Patent

active

060517166

ABSTRACT:
A process for preparing a compound of the formula I: ##STR1## or pharmaceutical acceptable salts thereof wherein X is --NR,--, --S(O).sub.g --, or --O--; R.sub.1 is --H, C.sub.1-6 alkyl optionally substituted with one or more --OH, --CN, or halo, or R.sub.1 is --(CH.sub.2).sub.h -aryl, --COR.sub.1-1, 13 COOR.sub.1-2, --CO--(CH.sub.2).sub.h --COR.sub.1-1, C.sub.1-6 alkyl sulfonyl, --SO.sub.2 --(CH.sub.2).sub.h -aryl, or --(CO).sub.i -Het; R.sub.2 is --H, C.sub.1-6 alkyl, --(CH.sub.2).sub.h -aryl, or halo; R.sub.3 and R.sub.4 are the same or different and are --H or halo; R.sub.5 is --H, C.sub.1-12 alkyl optionally substituted with one or more halo, C.sub.3-12 cycloalkyl, C.sub.1-6 alkoxy. The compounds are useful antimicrobial agents.

REFERENCES:
patent: 4476136 (1984-10-01), Dostert et al.
patent: 4948801 (1990-08-01), Carlson et al.
patent: 5130316 (1992-07-01), Carlson et al.
patent: 5254577 (1993-10-01), Carlson et al.

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