Phenyloctanamides

Details Phenyloctanamides Phenyloctanamides

2005-12-09

2009-11-10

Kumar, Shailendra (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C549S378000, C514S452000, C514S620000

Reexamination Certificate

active

07615664

ABSTRACT:
Compounds of the general formula (I) in which the substituents R, R1, R2, R3, R4, R5and R6are each as defined in claim1have renin-inhibiting properties and can be used as medicaments.

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Jeanette M. Wood et al., “Structure-based design of aliskiren, a novel orally effective renin inhibitor”, Biochemical and Biophysical Research Communications, Academic Press Inc., vol. 308, No. 4, pp. 698-705, XP004447169, ISSN: 0006-291X, Sep. 5, 2003.
Richard Göschke et al., “Design and synthesis of novel, 2,7-Dialkyl Substituted 5(S)-Amino-4(S)-Hydroxy-8-Phenyl-Octanecarboxamides as In Vitro Potent Peptidomimetic Inhibitors of Human Renin”, Bioorganic & Medicinal Chemistry Letters, vol. 7, No. 21, pp. 2735-2740, XP004136522, ISSN: 0960-894X, Nov. 4, 1997.

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