Phenylnaphthalene lactones as inhibitors of leukotriene biosynth

Details Phenylnaphthalene lactones as inhibitors of leukotriene biosynth Phenylnaphthalene lactones as inhibitors of leukotriene biosynth

1992-08-27

1994-09-27

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Azoxy doai

514278, 514316, 514318, 514337, 514826, 514912, 546 15, 546187, 546193, 546194, 546269, A61K 31655, A61K 3144, C07D40512

Patent

active

053507444

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.

REFERENCES:
patent: 4486445 (1984-12-01), Patel et al.
patent: 4937373 (1990-06-01), Carson et al.

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