Phenylisoquinoline derivatives as diagnostic agents

Details Phenylisoquinoline derivatives as diagnostic agents Phenylisoquinoline derivatives as diagnostic agents

1978-10-20

1980-06-10

Fagelson, Anna P.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424258, A61K 2900, A61K 3147, G01N 3316

Patent

active

042073090

ABSTRACT:
Derivatives of phenylisoquinoline, in particular 8-amino-2-methyl-4-phenyl-1,2,3,4-tetrahydro-iso-quinoline hydrogen maleate, are used as effective agents in the differential diagnosis of disorders of hypothalamo-pituitary function. The phenylisoquinoline derivatives are administered orally at a dose of about 1-5 mg/body wt. in order to differentiate between "functional" and "organic" (tumorous) diseases.

REFERENCES:
Muller et al., J. of Clin. Endocrin. & Metab. vol. 47, No. 6, 1978, pp. 1352-1357.
Scanlon et al., Chem. Abs. vol. 88, 1978, Ab. No. 99271r.

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