Phenylguanidines useful as anthelmintic agents

Details Phenylguanidines useful as anthelmintic agents Phenylguanidines useful as anthelmintic agents

1976-06-07

1977-06-28

Rosen, Sam

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424326, A61K 3127, A61K 31155

Patent

active

040326551

ABSTRACT:
N-[2-(Substituted amido)phenyl]-N',N"-bis-carbonylguanidines bearing an optionally substituted phenoxy, phenylthio, phenylsulfinyl or phenylsulfonyl group in the 4- or 5-position of the 2-(substituted amido)phenyl group are anthelmintic agents. The compounds, of which N-(2-acetamido-4-phenylthiophenyl)-N',N"-bis-carbomethoxyguanidine is a typical example, are prepared through the reaction of isothiourea-S-alkyl ether and an appropriately substituted 2-aminoanilide.

REFERENCES:
patent: 3636109 (1972-01-01), Hennis et al.
patent: 3828094 (1974-08-01), Widdig et al.

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