Phenylglycine derivatives useful for treating disorders of the c

Details Phenylglycine derivatives useful for treating disorders of the c Phenylglycine derivatives useful for treating disorders of the c

1997-05-09

1999-01-26

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514429, 514438, 514471, 514562, 514564, 548577, 549 77, 549496, 562432, 562437, 562441, 562443, 562444, 562449, A61K 31195, A61K 3134, A61K 3138, A61K 3140, C07C22936, C07C32128, C07D295155, C07D30754, C07D33324

Patent

active

058639470

ABSTRACT:
A pharmaceutical compound of the formula: ##STR1## in which R.sup.1 is hydrogen, hydroxy or C.sub.1-6 alkoxy, R.sup.2 is hydrogen, carboxy, tetrazolyl, --SO.sub.2 H, --SO.sub.3 H, --OSO.sub.3 H, --CONHOH, or --P(OH)OR', --PO(OH)OR', --OP(OH)OR' or --OPO(OH)OR' where R' is hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl or aryl C.sub.1-6 alkyl,

REFERENCES:
patent: 5238958 (1993-08-01), Johnson et al.
patent: 5610183 (1997-03-01), Owens et al.
"Structure-activity relationships of new agonists and antagonists of different motabotropic glutamate receptor subtypes", British Journal of Pharmacology (1996), vol. 117, pp. 1493-1503.
Chemical Abstarcts 110:6394 (1988).
Chemical Abstracts 107:176434 (1987).
Cas Registry No. 116435-35-9.
Harris, C.M. et al. Tetrahedron Letters,(8), 705-708 (1978).
Harris, C.M. et al. Journal of the American Chemical Society, 101(2), 437-445 (1979).

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