Phenylglycinamide derivatives useful as anticoagulants

Details Phenylglycinamide derivatives useful as anticoagulants Phenylglycinamide derivatives useful as anticoagulants

2006-01-09

2009-11-24

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S146000

Reexamination Certificate

active

07622585

ABSTRACT:
The present invention relates generally to phenylglycinamide derivatives that inhibit serine proteases. In particular it0 is directed to novel phenylglycinamide derivatives, and analogues thereof, which are useful as selective inhibitors of serine protease enzymes of the coagulation cascade; for example thrombin, factor VIIa, factor Xa, factor XIa, factor IXa, and/or plasma kallikrein. In particular, it relates to compounds that are factor VIIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of using the same.

REFERENCES:
patent: 5023236 (1991-06-01), Edgington et al.
patent: 5475106 (1995-12-01), Bourzat et al.
patent: 5602101 (1997-02-01), Schacht et al.
patent: 5843442 (1998-12-01), Soule et al.
patent: 5866542 (1999-02-01), Vlasuk et al.
patent: 6140353 (2000-10-01), Ackermann et al.
patent: 6194409 (2001-02-01), van Boeckel et al.
patent: 6242644 (2001-06-01), Ackermann et al.
patent: 6335324 (2002-01-01), Bisacchi et al.
patent: 6358960 (2002-03-01), Senokuchi et al.
patent: 6472393 (2002-10-01), Aliagas-Martin et al.
patent: 6642252 (2003-11-01), Bisacchi et al.
patent: 6699994 (2004-03-01), Babu et al.
patent: 6900207 (2005-05-01), Ohmoto et al.
patent: 2003/0166694 (2003-09-01), Dorsch et al.
patent: 2004/0176375 (2004-09-01), Bisacchi et al.
patent: 2004/0204412 (2004-10-01), Glunz et al.
patent: 2005/0107409 (2005-05-01), Priepke et al.
patent: 2006/0211720 (2006-09-01), Glunz et al.
patent: 2007/0003539 (2007-01-01), Zhang et al.
patent: 10310278 (2004-09-01), None
patent: WO 96/20689 (1996-07-01), None
patent: WO 97/10214 (1997-03-01), None
patent: WO 01/44172 (2001-06-01), None
patent: WO 01/90051 (2001-11-01), None
patent: WO 02/09688 (2002-02-01), None
patent: WO 02/34711 (2002-05-01), None
patent: WO 03/013531 (2003-02-01), None
patent: WO 03/066588 (2003-08-01), None
patent: WO 03/084533 (2003-10-01), None
patent: WO 2004/072101 (2004-08-01), None
patent: WO 2005/054430 (2005-06-01), None
Carson, S.D. et al., “The role of tissue factor in the production of thrombin”, Blood Coagulation and Fibrinolysis, vol. 4, pp. 281-292 (1993).
Colman, R.W., Chapter 6: “Contact Activation Pathway: Inflammatory, Fibrinolytic, Anticoagulant, Antiadhesive, and Antiangiogenic Activities”, Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 4thEd., Lippincott Williams & Wilkins, publ., Colman, R.W. et al., eds., pp. 103-121 (2001).
Girard, T.J. et al., “The role of tissue factor/factor Vlla in the pathophysiology of acute thrombotic formation”, Current Opinion in Pharmacology, vol. 1, pp. 159-163 (2001).
Goodnight, S.H. et al., Chapter 4: “Screening Tests of Hemostasis”, Disorders of Hemostasis and Thrombosis: A Clinical Guide, The McGraw-Hill Companies, publ., pp. 41-51 (2001).
Schmaier, A.H., Chapter 5: “Contact Activation”, Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 4thEd., Lippincott Williams & Wilkins, publ., Colman, R.W. et al., eds., pp. 105-127 (2001).

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