Phenylethl o-methylcinnamate, a process for preparation and a fr

Details Phenylethl o-methylcinnamate, a process for preparation and a fr Phenylethl o-methylcinnamate, a process for preparation and a fr

1989-05-11

1991-11-19

Reamer, James H.

Perfume compositions

Perfume compositions

Ring containing active ingredient

560104, A61K 746

Patent

active

050666401

ABSTRACT:
The invention relates to phenylethyl o-methylcinnamate and a process for its preparation. Phenylethyl o-methylcinnamate is prepared by, first, alkylating ethyl acetoacetate with o-methylbenzyl chloride in the presence of a phase transfer catalyst to yield 2-(o-methylbenzyl)-acetoacetate. Thereafter the 2-(o-methylbenzyl)-acetoacetate yielded in the alkylating step is halogenated to yield ethyl 2-halo-2-(o-methylbenzyl)-acetoacetate. This is followed by degarding the ethyl 2-halo-2-(o-methylbenzyl)-acetoacetate acid. Finally the o-methylcinnamic acid obtained in the degarding step is esterified with 2-phenylethanol into phenylethyl o-methylcinnamate. A fragrance composition utilizing phenylethyl o-methylcinnamate is also disclosed.

REFERENCES:
patent: 2246974 (1941-06-01), Coleman et al.
patent: 3074891 (1963-01-01), Kulka
patent: 4263359 (1981-05-01), Anderson et al.
patent: 4587260 (1986-05-01), Smerbeck et al.
Bohlmann et al., Chem. Abst., vol. 87, #35864h (1977).
Ninomiya et al., Chem. Abst., vol. 92, #31935n (1980).
Furia et al., "Fenaroli's Handbook of Flavor Ingredients", 2nd Edtn., vol. 2, p. 463 (1975).

Affiliated with

Also associated with

Rating

Phenylethl o-methylcinnamate, a process for preparation and a fr does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylethl o-methylcinnamate, a process for preparation and a fr, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylethl o-methylcinnamate, a process for preparation and a fr will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1370412