Phenylethanolamine-N-methyltransferase sequence variants

Details Phenylethanolamine-N-methyltransferase sequence variants Phenylethanolamine-N-methyltransferase sequence variants

2008-05-13

2008-05-13

Nashed, Nashaat T. (Department: 1656)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S195000, C435S015000, C536S023200, C536S024100

Reexamination Certificate

active

07371523

ABSTRACT:
Isolated PNMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PNMT allozymes. Methods for determining if a subject is predisposed to multiple sclerosis, early-onset Alzheimer's disease, or Parkinson's disease also are described.

REFERENCES:
patent: 5451683 (1995-09-01), Barrett et al.
patent: 5733729 (1998-03-01), Lipshutz et al.
patent: 5770722 (1998-06-01), Lockhart et al.
patent: 6660476 (2003-12-01), Comings et al.
patent: 2001/0053519 (2001-12-01), Fodor et al.
patent: WO98/20019 (1998-05-01), None
patent: WO99/57318 (1999-11-01), None
GeneBank Accession No. AC079199.9.
Aravinda chakravarti SNP Report submission: rs5638.
Chin, “On the preparation and utilization of isolated and purified oligonucleotides,” University of North Carolina, Mar. 9, 2002 (on CD due to large volume of pages).
GenBank Accession No. J03727 dated Jan. 8, 1995.
GenBank Accession No. X52730 dated Apr. 24, 1993.
Böttner et al., “Increased Body Fat Mass and Suppression of Circulating Leptin Levels in Response to Hypersecretion of Epinephrine in Phenylethanolamine-N-Methyltransferase (PNMT)-Overexpressing Mice,”Endocrinology,2000, 141(11):4239-4246.
Caine et al., “Recombinant human phenylethanolamine N-methyltransferase: overproduction inEscherichia coli,purification, and characterization,”Protein Expr. Purif.,1996, 8(2):159-166.
Chadwick et al., “Heterozygote and Mutation Detection by Direct Automated Fluorescent DNA Sequencing Using a MutantTaqDNA Polymerase,”BioTechniques,1996, 20:676-683.
Cibelli et al., “Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts,”Science,1998, 280:1256-1258.
Cleland, “Computer Programmes For Processing Enzyme Kinetic Data,”Nature,1963, 198:463-365.
Cote et al., “Generation of human monoclonal antibodies reactive with cellular antigens,”Proc. Natl. Acad. Sci. USA,1983, 80:2026-2030.
Cole et al., “The EBV-Hybridoma Technique and its Application to Human Lung Cancer,”Monoclonal Antibodies and Cancer Therapy,1985, Alan R. Liss, Inc., pp. 77-96.
Excoffier and Slatkin, “Maximum-Likelihood Estimation of Molecular Haplotype Frequencies in a Diploid Population,”Mol. Biol. Evol.,1995, 12(5):921-927.
Gearhart et al., “Phenylethanolamine N-methyltransferase has beta-carboline 2N-methyltransferase activity: hypothetical relevance to Parkinson's disease,”Neurochem. Int.,2002, 40(7):611-620.
Gordon et al., “Consed:A Graphical Tool for Sequence Finishing,”Genome Res.,1998, 8:195-202.
Guatelli et al., “Isothermal, in vitro amplification of nucleic acids by a multienzyme reaction modeled after retroviral replication,”Proc. Natl. Acad. Sci. USA,1990, 87:1874-1878.
Hacia et al., “Detection of heterozygous mutations inBRCAlusing high density oligonucleotide arrays and two-colour fluorescence analysis,”Nature Genet.,1996, 14:441-447.
Halushka et al., “Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis,”Nature Genet.,1999, 22:239-247.
Hartl and Clark, “Chromosomes and Heredity,”Principles of Population Genetics,3rd Edition, 1997, Sinauer Associates, Inc., Sunderland, MA, pp. 96-106.
Hedrick,Genetics of Populations,2nd Edition, 2000, Jones and Bartlett, Sudbury, MA, pp. 396-405.
Huse et al., “Generation of a Large Combinatorial Library of the Immunoglobulin Repertoire in Phage Lambda,”Science,1989, 246:1275-1281.
Hyrup and Nielsen, “Peptide Nucleic Acids (PNA): Synthesis, Properties and Potential Applications,”Bioorgan. Med. Chem.,1996, 4(1):5-23.
Kö{umlaut over ( )}hler and Milstein, “Continuous cultures of fused cells secreting antibody of predefined specificity,”Nature,1975, 256(5512):495-497.
Kozbor and Roder, “The production of monoclonal antibodies from human lymphocytes,”Immunology Today,1983, 4:72-79.
Lewis, “PCR's Competitors Are Alive and Well and Moving Rapidly Towards Commercialization,”Genetic Engineering News,1992, 12(9):1-3.
Long et al., “An E-M Algorithm and Testing Strategy for Multiple-Locus Haplotypes,”Am. J. Hum. Genet.,1995, 56:799-810.
Mann et al., “Association between the phnylethanolamine N-methyltransferase gene and multiple sclerosis,”J. Neuroimmunol.,2002, 124(1-2):101-105.
Mann et al., “Phenylethanolamine N-methyltransferase (PNMT) Gene and Early-Onset Alzheimer Disease,”Am. J. Med. Genet.,2001, 105(4):312-316.
Molinoff et al., “A Sensitive Enzymatic Assay for Dopamine-β-Hydroxylase,”J. Phamacol. Exp. Ther.,1971, 178(3):425-431.
Myakishev et al., “High-Throughput SNP Genotyping by Allele-Specific PCR with Universal Energy-Transfer-Labeled Primers,”Genome Research,2001, 11(1):163-169.
Nickerson et al., “PolyPhred: automating the detection and genotyping of single nucleotide substitutions using fluorescence-based resequencing,”Nucl. Acids Res.,1997, 25(14):2745-2751.
Prince et al., “Robust and Accurate Single Nucleotide Polymorphism Genotyping by Dynamic Allele-Specific Hybridization (DASH): Design Criteria and Assay Validation,”Genome Res.,2001, 11(1):152-162.
Schafer and Hawkins, “DNA variation and the future of human genetics,”Nat. Biotechnol.,1998, 16:33-39.
Shastry, “Gene disruption in mice: Models of development and disease,”Mol. Cell. Biochem.,1998, 181:163-179.
Stoneking et al., “Population Variation of Human mtDNA Control Region Sequences Detected by Enzymatic Amplification and Sequence-specific Oligonucleotide Probes,”Am. J. Hum. Genet.,1991, 48:370-382.
Summerton and Weller, “Morpholino Antisense Oligomers: Design, Preparation, and Properties,”Antisense Nucleic Acid Drug Dev.,1997, 7:187-195.
Tai et al., “Glucocorticoid Responsiveness of the Rat Phenylethanolamine N-methyltransferase Gene,”Mol. Pharmacol.,2002, 61(6):1385-1392.
Terwilliger and Ott, “Linkage Disequilibrium between Alleles at Marker Loci,”Handbook of Human Genetic Linkage,1994, The Johns Hopkins University Press, Baltimore, pp. 188-193.
Underhill et al., “Detection of Numerous Y Chromosome Biallelic Polymorphisms by Denaturing High-Performance Liquid Chromatography,”Genome Res.,1997, 7:996-1005.
Wakayama et al., “Full-term development of mice from enuleated oocytes injected with cumulus cell nuclei,”Nature,1998, 394(6691):369-374.
Warthan et al., “Phenylethanolamine N-methyl transferase expression in mouse thymus and spleen,”Brain Behav. Immun.,2002, 16(4):493-499.
Weiss, “Hot Prospect for New Gene Amplifier,”Science,1991, 254:1292-1293.
Wilkinson, “Statistical Estimations in Enzyme Kinetics,”Biochem. J.,1961, 80:324-332.
Wilmut et al., “Viable offspring derived from fetal and adult mammalian cells,”Nature,1997, 385(6619):810-813.
Wong et al., “Human GM-CSF: Molecular Cloning of the Complementary DNA and Purification of the Natural and Recombinant Proteins,”Science,1985, 228:810-815.
Begun et al., “Crystallization of PNMT, the adrenaline-synthesizing enzyme, is critically dependent on a high protein concentration,”Acta Crystallogr. D. Biol. Crystallogr., 2002, 58(Pt 2):314-315.
Burke et al., “Evidence for decreased transport of PNMT protein in advanced Alzheimer's disease,”J. Am. Geriatr. Soc., 1990, 38(12):1275-1282.
Comings, “Clinical and molecular genetics of ADHD and Tourette syndrome. Two related polygenic disorders,”Ann. N Y Acad. Sci. 2001, 931:50-83.
Dubb et al., “Studies with a PNMT inhibitor,”Clin. Pharmacol. Ther., 1979, 25(6):837-844.
Grunewald et al., “Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme,”Bioorg. Med. Chem. Lett., 2001, 11(12):1579-1582.
Hemmick et

Affiliated with

Also associated with

Rating

Phenylethanolamine-N-methyltransferase sequence variants does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylethanolamine-N-methyltransferase sequence variants, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylethanolamine-N-methyltransferase sequence variants will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2749662