Phenylethanolamine compounds as β 2 -receptor...

Details Phenylethanolamine compounds as β 2 -receptor... Phenylethanolamine compounds as β 2 -receptor...

2006-08-29

2006-08-29

Davis, Brian (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C514S653000

Reexamination Certificate

active

07098364

ABSTRACT:
The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein R1is H, chlorine, or bromine; R2is electron attractive groups selected from the group consisting of CF3, CN, fluorine, CH3SO3, CF3SO3, and NO2; R3is linear or branched alkyl having 1 to 10 carbon atoms, linear or branched alkoxyalkyl having 2 to 10 carbon atoms, aliphatic alcohol having 1 to 10 carbon atoms, or cycloalkyl having 3 to 6 carbon atoms. The invention also relates to methods for preparing the said compounds and the composition comprising the same. The compounds of the present invention have the effect of β2-receptor agonist and can be used for the treatment of asthma and bronchitis

REFERENCES:
Database CAPLUS on STN, Acc. No. 1997:132857, Brodfuehrer et al., Organic Process Research & Development (1997), 1(2), p. 176-178 (abstract).
Database CAPLUS on STN, Acc. No. 2001:86611, Boger et al., Journal of the American Chemical Society (2001), 123(9), p. 1862-1871 (abstract).

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