Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1988-06-03
1990-01-23
Siegel, Alan
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
549 79, A61K 338, C07D33322
Patent
active
048958697
ABSTRACT:
This invention related to leukotriene B.sub.4 antagonists having the structure ##STR1## and the pharmaceutically acceptable addition salts thereof; wherein R.sup.1 is lower alkyl having 1-10 carbon atoms; or lower alkenyl or alkynyl having 2-10 carbon atoms; or lower alkadienyl having 3-10 carbon atoms; or lower alkadienyl or alkenynyl having 4-10 carbon atoms;
REFERENCES:
patent: 4546194 (1985-10-01), Miyano
patent: 4791133 (1988-12-01), Djuric et al.
Furber et al., J. Chem. Soc. Perkins.Trans I, (7): 1573-78 (1987).
Biochem and Biopys. Res. Comm., 138, 540-546 (1986).
Lewis, et al., J. Clin. Inves., 73, 889-897 (1984).
Bray, Brit. Medical Bull., 39, 249-254 (1983).
Djuric Stevan W.
Haack Richard A.
Miyashiro Julie M.
C. D. Searle & Co.
Kanady M. J.
Matukaitis P. D.
Siegel Alan
Williams R. A.
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