Phenylene di-ethers

Details Phenylene di-ethers Phenylene di-ethers

1974-02-01

1976-12-21

Hines, Robert V.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260348R, 2605707, 260612D, 260625, 424316, 424330, C07C 9306

Patent

active

039988740

ABSTRACT:
Substituted phenylene di-ethers of the formula; ##STR1## wherein R represents an isopropyl or tertiary butyl group and X represents hydrogen or lower alkyl, and acid addition salts thereof.
The compounds are useful anti-arrhythmic agents and also show local anaesthetic activity in mammals. Their methods of preparation are disclosed and also pharmacological preparations containing the same.

REFERENCES:
patent: 3033640 (1962-05-01), Hofer et al.
patent: 3432545 (1969-03-01), Hoove
patent: 3555161 (1971-01-01), Brandstrom et al.
patent: 3872147 (1975-03-01), Koppe et al.
Terentev et al., "Chemical Abstracts", vol. 57, pp. 16455-16456 (1962).

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