Phenylcyclohexylpropanolamine derivatives, preparation and...

Details Phenylcyclohexylpropanolamine derivatives, preparation and... Phenylcyclohexylpropanolamine derivatives, preparation and...

2003-05-26

2008-11-18

Davis, Brian J (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S099000, C564S399000, C562S429000, C560S012000, C560S013000, C549S445000, C548S491000, C514S464000, C514S415000, C514S538000, C514S562000, C514S605000

Reexamination Certificate

active

07453010

ABSTRACT:
The invention relates to compounds of general formula (I):where R1represents H or a (C1-C4)alkyl, —CO(C1-C4)alkyl, (C1-C4)alkylphenyl or —CO-phenyl group, said phenyl optionally being substituted; R2represents H, a halogen atom, an —S(O)z(C1-C4)alkyl group, where z is equal to 0, 1 or 2, an —NHSO2(C1-C4)alkyl group, an —NHSO2-phenyl group or an —NHSO2—(C1-C4)alkylphenyl group, said phenyl optionally being substituted; R3represents an —X—R4group—in which X represents a bond, an oxygen atom or a —CH2— group and R4represents H or a —CR5R6—COOR7group, where R5, R6and R7independently represent H or a (C1-C4)alkyl group—a phenyl group optionally substituted or fused with a dioxolane group, a —CO—NR8R9group—where R8represents H, a (C1-C4)alkyl group or a (C1-C4)alkyl(C1-C4)alkoxy group and R9represents a (C1-C4)alkyl(C1-C4)alkoxy group, a —(CH2)n-A group, where n is equal to 0, 1, 2, 3 or 4 and where A represents an indolyl group, a fluorenyl group or a phenyl group which is substituted, an optionally substituted —NH-phenyl group or a —CH(R10)—(CH2)n—COOR11group, where n is 0, 1, 2 or 3 and where R11represents H or a (C1-C4)alkyl group and R10represents H, a (C1-C4)alkyl group or a —CH2-phenyl group, said phenyl optionally being substituted, or a —COOR12group, where R12represents H or a (C1-C4)alkyl group; their process of preparation and their therapeutic application.

REFERENCES:
patent: 4004028 (1977-01-01), Kaiser
Derwent Patent Abstract No. 200248 (2004).
Derwent Patent Abstract No. 200011 (2004).

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