Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N

Details Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N Phenylcarbamates of (-)-eseroline, (-)-N1-noreseroline and (-)-N

1993-07-26

1999-12-07

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548429, A61K 3140, C07D48704

Patent

active

059984600

ABSTRACT:
The present invention relates to eseroline, N.sup.1 -noreseroline, and N.sup.1 -benzylnoreseroline phenyl carbamate analogues which provide highly potent and selective cholinergic agonist and blocking activity and their use as pharmaceutical agents. The invention further relates to improvements in therapeutic methods related to diseases such as glaucoma, myasthenia gravis, alzheimer's disease and to improvements in therapy related to organophosphate poisoning. The invention further provides for selective acetyl-cholinesterase and butyrylcholinesterase agents and a method for inhibiting these esterases.

REFERENCES:
patent: 4900748 (1990-02-01), Brossi
patent: 5081117 (1992-01-01), Glamkowski et al.
Yu et al., J. Med. Chem., vol. 31, pp. 2297-2300 (1988).
Atack et al., J. Pharm. Exp. Ther., vol. 249, No. 3., pp. 194-202 (1989).
Yu et al., Heterocycles, vol. 27, No. 3, pp. 745-750 (1988).
Marta et al., Chemical Abstracts vol. 110, No. 9, Abst. 69253 (1989).
Yu et al., FEBS Lett., vol. 234, No. 1, pp. 127-130 (1988).
Yu, Qian-sheng et al. Helvetica Chimca ACTA, vol. 74, (1991) pp. 761-766.
Beilstein, Ed. II, vol. 23, 1954, p. 333.

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