Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1996-05-28
2000-08-01
Davis, Zinna Northington
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514372, 514374, 514378, 514365, 514406, 514407, 514423, 514427, 514471, 514617, 544335, 548200, 548203, 548236, 548247, 548248, 5483741, 5483751, 548561, 549487, 549491, C07D23924, A61K 31505, A61K 3104
Patent
active
060967471
ABSTRACT:
##STR1## Compounds of formula (1) are described wherein Y represents a halogen atom or a group --OR.sup.1 where R.sup.1 represents an optionally substituted alkyl group; R.sup.2 represents an optionally substituted cycloalkyl, cycloalkenyl or polycycloalkyl group; R.sup.3 represents a hydrogen atom or an alkyl, aryl or aralkyl group; R.sup.4 represents an aryl or heteroaryl group; X represents --O--, --S--, --CH.sub.2 -- or --N(R.sup.5)--, where R.sup.5 is a hydrogen atom or an alkyl group; n is zero or an integer or value 1, 2 or 3; and the salts, solvates and hydrates thereof. The compounds are selective phosphodiesterase IV inhibitors and are useful for the prophylaxis or treatment of inflammatory diseases.
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Beeley Nigel Robert Arnold
Millican Thomas Andrew
Celltech Therapeutics Limited
Davis Zinna Northington
LandOfFree
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