Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-04-12
2005-04-12
Raymond, Richard L. (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S255050, C514S300000, C514S455000, C514S570000, C544S230000, C546S015000, C560S051000, C560S053000, C562S459000, C562S465000
Reexamination Certificate
active
06878718
ABSTRACT:
Phenylalanine enamide derivatives of formula (1) are described:whereinR1is a group Ar1L2Ar2Alk- in which:Ar1is an optionally substituted aromatic or heteroaromatic group;L2is a covalent bond or a linker atom or group;Ar2is an optionally substituted arylene or heteroarylene group;and Alk is a chain—CH2—CH(R)—, —CH═C(R)— or in which R is a carboxylic acid (—CO2H) or a derivative or biostere thereof;X is an —O— or —S— atom or —N(R2)— group in which:Rx, Ryand Rzwhich may be the same or different is each a hydrogen atom or an optional substituent;or Rzis an atom or group as previously defined and Rxand Ryare joined together to form an optionally substituted spiro linked cycloaliphatic or heterocycloaliphatic group;and the salts, solvates, hydrates and N-oxides thereof.The compounds are able to inhibit the binding of integrins to their ligands and are of use in the prophylaxis and treatment of immuno or inflammatory disorders or disorders involving the inappropriate growth or migration of cells.
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Bailey Stuart
Brand Stephen
Brown Julien A.
Head John C.
Johnson James A.
Celltech R&D Limited
Raymond Richard L.
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