Phenylalanine derivatives as endothelin antagonists

Details Phenylalanine derivatives as endothelin antagonists Phenylalanine derivatives as endothelin antagonists

1995-01-05

1997-08-19

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514538, 514539, 514562, 514563, 514567, 514 63, 514617, 514464, 560 40, 562439, 562446, 549435, 549444, 556419, C07C22936, C07C22930, C07C31760

Patent

active

056589433

ABSTRACT:
Novel antagonists of endothelin are described, as well as novel intermediates used in their preparation, methods for the preparation and pharmaceutical compositions of the same, which are useful in treating elevated levels of endothelin, essential, renovascular, malignant and pulmonary hypertension, cerebral infarction, myocardial ischemia, cerebral ischemia, congestire heart failure and subarachnoid hemorrhage.

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