Phenylalanine derivatives

Details Phenylalanine derivatives Phenylalanine derivatives

2011-01-18

2011-01-18

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S285000, C514S266100, C514S266310

Reexamination Certificate

active

07872125

ABSTRACT:
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.

REFERENCES:
patent: 4223039 (1980-09-01), Rose et al.
patent: 6306840 (2001-10-01), Adams et al.
patent: 6610710 (2003-08-01), Tanaka et al.
patent: 6855706 (2005-02-01), Satake et al.
patent: 7105520 (2006-09-01), Suzuki et al.
patent: 7153963 (2006-12-01), Makino et al.
patent: 7160874 (2007-01-01), Tanaka et al.
patent: 7193108 (2007-03-01), Chiba et al.
patent: 7250516 (2007-07-01), Okuzumi et al.
patent: 7345049 (2008-03-01), Sagi et al.
patent: 2003/0220318 (2003-11-01), Suzuki et al.
patent: 2005/0101779 (2005-05-01), Sagi et al.
patent: 2006/0009476 (2006-01-01), Kataoka et al.
patent: 2006/0223836 (2006-10-01), Makino et al.
patent: 2007/0018172 (2007-01-01), Takahashi et al.
patent: 2008/0108637 (2008-05-01), Fujita et al.
patent: 101841 (1997-08-01), None
patent: 1067431 (1992-12-01), None
patent: 2 354 440 (2001-03-01), None
patent: 0000914 (2001-04-01), None
patent: 755193 (1980-08-01), None
patent: WO 02/28830 (1992-04-01), None
patent: 99/06437 (1999-02-01), None
patent: WO 99/06431 (1999-02-01), None
patent: 99/10312 (1999-03-01), None
patent: WO 99/10312 (1999-03-01), None
patent: WO 99/10313 (1999-03-01), None
patent: WO 99/35163 (1999-07-01), None
patent: WO 99/36393 (1999-07-01), None
patent: WO 99/37618 (1999-07-01), None
patent: WO 99/43642 (1999-09-01), None
patent: WO 01/36376 (2001-05-01), None
patent: WO 01/42215 (2001-06-01), None
patent: WO 01/42225 (2001-06-01), None
patent: WO 01/47868 (2001-07-01), None
patent: WO 01/70670 (2001-09-01), None
patent: WO 02/02556 (2002-01-01), None
patent: WO 02/18320 (2002-03-01), None
The Merck Manual, 16thEd., 1992, pp. 1488-1489.
U.S. Appl. No. 12/470,846, filed May 22, 2009, Kataoka, et al.
U.S. Appl. No. 11/767,969, filed Jun. 25, 2007, Okuzumi, et al.
U.S. Appl. No. 11/430,284, filed May 9, 2006, Makino, et al.
U.S. Appl. No. 11/963,144, filed Dec. 21, 2007, Sagi, et al.
Angela Zeidler et al, “Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-induced Arthristis”,Autoimmunity, 1995, vol 21, pp. 245-252.
Daniel K. Podolsky et al. “Attenuation of Colitis in the Cotton-top Tamarin by Anti-α4 integrin Monocolonal Antibody”.J. Clin. Invest, Jul. 1993, vol. 92, pp. 372-380.
Tsutomu Takeuchi et al, “Upregulated Expression and Function of Integrin Adhesive Receptors in Systemic Lupus Erythematosus Patients with Vasculitis”,J. Clin. Invest., Dec. 1993, vol. 92, pp. 3008-3016.
S.M. Wellicome et al, “Detection of a circulating form of vascular cell adhesion molecule-1:raised levels in rheumatoid arthritis and systemic lupus erythematosus”,Clin. Exp. Immunol., 1993, vol. 92, pp. 412-418.
Ted. A. Yednock et al, “Prevention of experimental autoimmune encephalomyelitis by antiboides against α4β1 integrin”.Nature, Mar. 5, 1992, vol. 356, pp. 63-66.
Jody L. Baron et al, “Surface Expression of α4 integrin by CD4 T Cells is Required for Their Entry into Brain Parenchyma”.J. Exp. Med., Jan. 1993, vol. 177, pp. 57-68.
Ichiro Saito et al., “Expression of Cell Adhesion Molecules in the Salivary and Lacrimal Glands of Sjogren's Syndrome”.Journal of Clinical Laboratory Analysis, 1993, vol. 7, pp. 180-187.
William M. Abraham et al. “a4-Integrins Mediate Antigen-induced Late Bronchial Responses and Prolonged Airway Hyperresponsiveness in Sheep”,J. Clin. Invest., Feb. 1994, vol. 93, pp. 776-787.
Hironori Sagara et al. “A Monoclonal against Very Late Activation Antigen-4 Inhibits Eosinophil Accumulation and Late Asthmatic Responses in a Guinea Pig Model of Asthma”,Int. Arch. Allergy Immunol., 1997, vol. 112, pp. 287-294.
Sumi Onuma, “Immunohistochemical Studies of Infiltrating Cells in early and Chronic Lesions of Psoriasis”,The Journal of Dermatology., 1994, vol. 21, pp. 223-232.
Toshinori Matsui et al, “Effects of anti-VLA-4 Monoclonal Antibody Treatment in Murine Model of Allergic Rhinitis”,Acta Otolaryngol., 2000, vol. 120, pp. 761-765.
Nobuyuki Ebihara et al, “Anti VLA-4 monoclonal antibody inhibits eosinophil infilitration in allergic conjunctivitis model of guinea pig”,Current Eve Research1999, vol. 19, No. 1, pp. 20-25.
Jody L. Baron et al, “The Pathogenesis of Adoptivie Murine Autoimmune Diabetes Requires an interaction between α4-integrins and Vascular Cell Adhesion Molecule-1”,J. Clin. Invest., Apr. 1994, vol. 93, pp. 1700-1708.
Simcha R. Meisel et al, “Increased Expression of Neutrophil and Monocyte Adhesion Molecules LFA-1, and Mac-1 and Their Ligand ICAM-1 and VLA-4 Throughout the Acute Phase of Myocardinal Infarction”,JACC, Jan. 1998, vol. 31, No. 1, pp. 120-125.
Peggy T. Shih et al, “Blocking Very Late Antigen-4 Integrin Decreases Leukocyte Entry and Fatty Streak Formation in Mice Fed an Atherogenic Diet”,Circ. Res., Feb. 19, 1999, vol. 84, pp. 345-351.
Alan B. Lumsden et al, “Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates”,Journal of Vascular Surgery, Jul. 1997, vol. 26, No. 1, pp. 87-93.
Yoshihisa Mori et al, “Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis”,Blood, Oct. 1, 2004, vol. 104, No. 7, pp. 2149-2154.
Hitoshi Okahara et al, “Involvement of Very Late Activation Antigen 4 (VLA-4) and Vascular Cell Adhesion Molecule 1(VCAM-1) in Tumor Necrosis Factor α Enhancement of Experimental Metastasis”,Cancer Research, Jun. 15, 1994, vol. 54, pp. 3233-3236.
Mitsuaki Isobe et al, “Immunosuppression to Cardiac Allografts and Soluble Antigens by Anti-Vascular Cellular Adhesion Molecule-1 and Anti-Very Late Antigen-4 Monoclonal Antibodies”,The Journal of Immunology, 1994, vol. 153, pp. 5810-5818.
Yoji Shimizu et al, “Integrins in the Immune System”Advances in Immunology, 1999, vol. 72, pp. 325-380.

Affiliated with

Also associated with

Rating

Phenylalanine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenylalanine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylalanine derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2644898