Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-07-31
2007-07-31
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C546S153000, C514S311000, C514S312000, C514S314000
Reexamination Certificate
active
10866260
ABSTRACT:
Phenylalanine derivatives of the following formula, analogues thereof and pharmaceutically acceptable salts thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents or preventive agents for various diseases concerning α4 integrin in which α4 integrin-depending adhesion process participates in the pathology, such as inflammatory diseases, rheumatoid arthritis, inflammatory bowel diseases, systemic lupus erythematosus, multiple sclerosis, Sjögren's syndrome, asthma, psoriasis, allergy, diabetes, cardiovascular diseases, arterial sclerosis, restenosis, tumor proliferation, tumor metastasis and transplantation rejection.wherein R1 is a methyl group and R2 is a methoxy group.
REFERENCES:
patent: 6229011 (2001-05-01), Chen et al.
patent: 6455550 (2002-09-01), Chen et al.
patent: 6610710 (2003-08-01), Tanaka et al.
patent: 6855706 (2005-02-01), Tanaka et al.
patent: 2004/0235848 (2004-11-01), Okuzumi et al.
patent: 190990 (2003-09-01), None
patent: WO 99/10312 (1999-03-01), None
patent: WO 99/10313 (1999-03-01), None
patent: WO 99/35163 (1999-07-01), None
patent: WO 99/36393 (1999-07-01), None
patent: WO 99/37618 (1999-07-01), None
patent: WO 01/36376 (2001-05-01), None
patent: WO 01/42215 (2001-06-01), None
patent: WO 01/42225 (2001-06-01), None
patent: WO 02/16329 (2002-02-01), None
patent: WO 02/28830 (2002-04-01), None
Fera,I J of Clin Invest, vol. 116 (3), pp. 715-723, Mar. 2006.
Engelhardt, Eur J Immunol, vol. 35, pp. 2268-2273, 2005.
Xiaoli, J of Leukocyte Biology, vol. 75, pp. 1016-1021, Jun. 2004.
Sandbom, American J of Gastroenterology, vol. 98(11), pp. 2372-2382, 2003.
Foster, J Allergy Clin Immunol, vol. 98, No. 6 part 2, pp. S270-S277, 1996.
Dostal, V., et al., “Determination of Acids and Their Strength in Isobutyl Methyl Ketone,” Collection of Czechoslovak Chemical Communications, vol. 47, No. 4, 1982, pp. 1203-1215, XP002405365.
U.S. Appl. No. 11/018,226, filed Dec. 22, 2004, Sagi et al.
U.S. Appl. No. 10/866,260, filed Jun. 14, 2004, Okuzumi et al.
U.S. Appl. No. 10/866,260, filed Jun. 14, 2004, Okuzumi et al.
U.S. Appl. No. 10/921,929, filed Aug. 20, 2004, Sagi et al.
J.W. Tilley, et al., “Imide and Lactam Derivatives of N-Benzylpyroglutamyl-L-Phenylalanine as VCAM/VLA-4 Antagonists”, Bioorganic & Medicinal Chemistry Letters, 11, 2001, pp. 1-4.
U.S. Appl. No. 10/300,856, filed Nov. 21, 2002, Makino et al.
U.S. Appl. No. 10/150,067, filed May 20, 2002, Tanaka et al.
U.S. Appl. No. 10/252,003, filed Sep. 23, 2002, Suzuki et al.
U.S. Appl. No. 10/402,006, filed Mar. 31, 2003, Suzuki et al.
U.S. Appl. No. 10/763,237, filed Jan. 26, 2004, Chiba et al.
Murata Masahiro
Nakanishi Eiji
Okuzumi Tatsuya
Ono Miho
Sagi Kazuyuki
Ajinomoto Co. Inc.
Seaman D. Margaret
LandOfFree
Phenylalanine derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenylalanine derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenylalanine derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3798384