Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-01-09
2007-01-09
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S217110, C514S224200, C514S230500, C514S231200, C514S255010, C514S266230, C514S249000, C514S327000, C514S423000, C514S563000, C544S041000, C544S105000, C544S168000, C544S169000, C544S285000, C544S349000, C544S391000
Reexamination Certificate
active
10986829
ABSTRACT:
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin.
REFERENCES:
patent: 6403584 (2002-06-01), de Laszlo et al.
patent: 6420418 (2002-07-01), Hagmann et al.
patent: 6579889 (2003-06-01), de Laszlo et al.
patent: 6610710 (2003-08-01), Tanaka et al.
patent: 2003/0130320 (2003-07-01), Suzuki et al.
patent: 358398 (1990-03-01), None
patent: WO 91/13054 (1991-09-01), None
patent: WO 99/10312 (1999-03-01), None
patent: WO 99/10313 (1999-03-01), None
patent: WO 99/36393 (1999-07-01), None
patent: WO 01/12183 (2001-02-01), None
Casanova et al., PubMed Abstract (Rev Neurol. 28(9):909-15) May 1999.
Simone, Oncology: Introduction, Cecil Textbook of Medicine, 20thEdition, vol. 1, pp. 1004-1010, 1996.
Tarkowski et al., PubMed Abstract (Int Arch Allergy Immunol. 121(1):25-33) Jan. 2000.
Griffioen et al, Tumor Angiogenesis is Accompanied by a Decreased Inflammatory Response of Tumor-Associated Endothelium, Blood, vol. 88, No. 2, pp. 667-673, 1996.
Mann et al, Cell Cycle Inhibition Preserves Endothelial Function in Genetically Engineered Rabbit Vein Grafts, J. Clin. Invest., vol. 99, No. 6, pp. 1295-1301, Mar. 1997.
Spragg et al, Immunotargeting of liposomes to activated vascular endothelial cells: A strategy for site-selective delivery in the cardiovascular system, Proc. Natl. Acad. Sci. USA, vol. 94, pp. 8795-8800, Aug. 1997.
Humphries et al, PubMed Abstract (Ciba Found Symp. 189:177-91, discussion 191-9, 1995.
Lobb et al, PubMed Abstract (Ann. NY Acad. Sci. 796:113-23), Oct. 1996.
Foster, PubMed Abstract (J. Allergy Clin. Immunol. 98 (6 Pt. 2): S 270-7, Dec. 1996.
Angela Zeidler et al, “Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-Induced Arthritis”,Autoimmunity,1995, vol. 21, pp. 245-252.
Daniel K. Podolsky et al, “Attenuation of Colitis in the Cotton-top Tamarin by Anti-α4 integrin Monoclonal Antibody”,J. Clin. Invest.,Jul. 1993, vol. 92, pp. 372-380.
Tsutomu Takeuchi et al, “Upregulated Expression and Function of Integrin Adhesive Receptors in Systemic Lupus Erythematosus Patients with Vasculitis”,J. Clin. Invest.,Dec. 1993, vol. 92, pp. 3008-3016.
S. M. Wellicome et al, “Detection of a circulating form of vascular cell adhesion molecule-1:raised levels in rheumatoid arthritis and systemic lupus erythematosus”,Clin. Exp. Immunol.,1993, vol. 92, pp. 412-418.
Ted A. Yednock et al, “Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin”,Nature,Mar. 5, 1992, vol. 356, pp. 63-66.
Jody L. Baron et al, “Surface Expression of α4 Integrin by CD4 T Cells Is Required for Their Entry into Brain Parenchyma”,J. Exp. Med.,Jan. 1993, vol. 177, pp. 57-68.
Ichiro Saito et al, “Expression of Cell Adhesion Molecules in the Salivary and Lacrimal Glands of Sjogren's Syndrome”,Journal of Clinical Laboratory Analysis,1993, vol. 7, pp. 180-187.
William M. Abraham et al, “α4-Integrins Mediate Antigen-induced Late Bronchial Responses and Prolonged Airway Hyperresponsiveness In Sheep”,J. Clin. Invest.,Feb. 1994, vol. 93, pp. 776-787.
Hironori Sagara et al, “A Monoclonal Antibody against Very Late Activation Antigen-4 Inhibits Eosinophil Accumulation and Late Asthmatic Response in a Guinea Pig Model of Asthma”,Int. Arch. Allergy Immunol.,1997, vol. 112, pp. 287-294.
Sumi Onuma, “Immunohistochemical Studies of Infiltrating Cells in Early and Chronic Lesions of Psoriasis”,The Journal of Dermatology,1994, vol. 21, pp. 223-232.
Toshinori Matsui et al, “Effects of anti-VLA-4 Monoclonal Antibody Treatment in Murine Model of Allergic Rhinitis”,Acta Otolaryngol.,2000, vol. 120, pp. 761-765.
Nobuyuki Ebihara et al, “Anti VLA-4 monoclonal antibody inhibits eosinophil infiltration in allergic conjunctivitis model of guinea pig”,Current Eye Research,1999, vol. 19, No. 1, pp. 20-25.
Jody L. Baron et al, “The Pathogenesis of Adoptive Murine Autoimmune Diabetes Requires an Interaction between α4- Integrins and Vascular Cell Adhesion Molecule-1”,J. Clin. Invest.,Apr. 1994, vol. 93, pp. 1700-1708.
Simcha R. Meisel et al, “Increased Expression of Neutrophil and Monocyte Adhesion Molecules LFA-1 and Mac-1 and Their Ligand ICAM-1 and VLA-4 Throughout the Acute Phase of Myocardial Infarction”,JACC,Jan. 1998, vol. 31, No. 1, pp. 120-125.
Peggy T. Shih et al, “Blocking Very Late Antigen-4 Integrin Decreases Leukocyte Entry and Fatty Streak Formation in Mice Fed an atherogenic Diet”,Circ. Res.,Feb. 19, 1999, vol. 84, pp. 345-351.
Alan B. Lumsden et al, “Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates”,Journal of Vascular Surgery,Jul. 1997, vol. 26, No. 1, pp. 87-93.
Yoshihisa Mori et al, “Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis”,Blood,Oct. 1, 2004, vol. 104, No. 7, pp. 2149-2154.
Hitoshi Okahara et al, “Involvement of Very Late Activation Antigen 4 (VLA-4) and Vascular Cell Adhesion Molecule 1 (VCAM-1) in Tumor Necrosis Factor α Enhancement of Experimental Metastasis”,Cancer Research,Jun. 15, 1994, vol. 54, pp. 3233-3236.
Mitsuaki Isobe et al, “Immunosuppression to Cardiac Allografts and Soluble Antigens by Anti-Vascular Cellular Adhesion Molecule-1 and Anti-Very Late Antigen-4 Monoclonal Antibodies”,The Journal of Immunology,1994, vol. 153, pp. 5810-5818.
Yoji Shimizu et al, “Integrins in the Immune System,”Advances in Immunology,1999, vol. 72., pp. 325-380.
Ejima Chieko
Izawa Hiroyuki
Kojima Mitsuhiko
Makino Shingo
Murata Masahiro
Ajinomoto Co. Inc.
Rao Deepak
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