Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...
Reexamination Certificate
2006-12-26
2006-12-26
Jiang, Shaojia A. (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitrogen attached directly or indirectly to the purine ring...
C544S309000, C546S141000, C546S142000, C514S269000
Reexamination Certificate
active
07153963
ABSTRACT:
Specified phenylalanine derivatives and analogues thereof have an antagonistic activity to α4 integrin. They are used as therapeutic agents for various diseases concerning α4 integrin
REFERENCES:
patent: 1067431 (1992-12-01), None
patent: 2 354 440 (2001-03-01), None
patent: WO 02/28830 (1992-04-01), None
patent: WO 99/06431 (1999-02-01), None
patent: WO 99/10312 (1999-03-01), None
patent: WO 99/10313 (1999-03-01), None
patent: WO 99/35163 (1999-07-01), None
patent: WO 99/36393 (1999-07-01), None
patent: WO 99/37618 (1999-07-01), None
patent: WO 99/43642 (1999-09-01), None
patent: WO 01/36376 (2001-05-01), None
patent: WO 01/42215 (2001-06-01), None
patent: WO 01/42225 (2001-06-01), None
patent: WO 01/47868 (2001-07-01), None
patent: WO 01/70670 (2001-09-01), None
patent: WO 02/02556 (2002-01-01), None
patent: WO 02/18320 (2002-03-01), None
Angela Zeidler et al, “Therapeutic Effects of Antibodies Against Adhesion Molecules in Murine Collagen Type II-Induced Arthritis”,Autoimmunity, 1995, vol. 21, pp. 245-252.
Daniel K. Podolsky et al, “Attenuation of Colitis in the Cotton-top Tamarin by Anti-α4 integrin Monoclonal Antibody”,J. Clin. Invest., Jul. 1993, vol. 92, pp. 372-380.
Tsutomu Takeuchi et al, “Upregulated Expression and Function of Integrin Adhesive Receptors in Systemic Lupus Erythematosus Patients with Vasculitis”,J. Clin. Invest., Dec. 1993, vol. 92, pp. 3008-3016.
S. M. Wellicome et al, “Detection of a circulating form of vascular cell adhesion molecule-1:raised levels in rheumatoid arthritis and systemic lupus erythematosus”,Clin. Exp. Immunol., 1993, vol. 92, pp. 412-418.
Ted A. Yednock et al, “Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin”,Nature, Mar. 5, 1992, vol. 356, pp. 63-66.
Jody L. Baron et al, “Surface Expression of α4 Integrin by CD4 T Cells Is Required for Their Entry into Brain Parenchyma”,J. Exp. Med., Jan. 1993, vol. 177, pp. 57-68.
Ichiro Saito et al, “Expression of Cell Adhesion Molecules in the Salivary and Lacrimal Glands of Sjogren's Syndrome”,Journal of Clinical Laboratory Analysis, 1993, vol. 7, pp. 180-187.
William M. Abraham et al, “α4-Integrins Mediate Antigen-induced Late Bronchial Responses and Prolonged Airway Hyperresponsiveness in Sheep”,J. Clin. Invest., Feb. 1994, vol. 93, pp. 776-787.
Hironori Sagara et al. “A Monoclonal Antibody against Very Late Activation Antigen-4 Inhibits Eosinophil Accumulation and Late Asthmatic Response in a Guinea Pig Model of Asthma”,Int. Arch. Allergy Immunol., 1997, vol. 112, pp. 287-294.
Sumi Onuma, “Immunohistochemical Studies of Infiltrating Cells in Early and Chronic Lesions of Psoriasis”,The Journal of Dermatology, 1994, vol. 21, pp. 223-232.
Toshinori Matsui et al, “Effects of anti-VLA-4 Monoclonal Antibody Treatment in Murine Model of Allergic Rhinitis”,Acta Otolaryngol., 2000, vol. 120, pp. 761-765.
Nobuyuki Ebihara et al, “Anti VLA-4 monoclonal antibody inhibits eosinophil infiltration in allergic conjunctivitis model of guinea pig”,Current Eye Research, 1999, vol. 19, No. 1, pp. 20-25.
Jody L. Baron et al, “The Pathogenesis of Adoptive Murine Autoimmune Diabetes Requires an Interaction between α4-Integrins and Vascular Cell Adhesion Molecule-1”,J. Clin. Invest., Apr. 1994, vol. 93, pp. 1700-1708.
Simcha R. Meisel et al, “Increased Expression of Neutrophil and Monocyte Adhesion Molecules LFA-1 and Mac-1 and Their Ligand ICAM-1 and VLA-4 Throughout the Acute Phase of Myocardial Infarction”,JACC, Jan. 1998, vol. 31, No. 1, pp. 120-125.
Peggy T. Shih et al, “Blocking Very Late Antigen-4 Integrin Decreases Leukocyte Entry and Fatty Streak Formation in Mice Fed an Atherogenic Diet”,Circ. Res., Feb. 19, 1999, vol. 84, pp. 345-351.
Alan B. Lumsden et al, “Anti-VLA-4 antibody reduces intimal hyperplasia in the endarterectomized carotid artery in nonhuman primates”,Journal of Vascular Surgery, Jul. 1997, vol. 26, No. 1, pp. 87-93.
Yoshihisa Mori et al, “Anti-α4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis”,Blood, Oct. 1, 2004, vol. 104, No. 7, pp. 2149-2154.
Hitoshi Okahara et al, “Involvement of Very Late Activation Antigen 4 (VLA-4) and Vascular Cell Adhesion Molecule 1 (VCAM-1) in Tumor Necrosis Factor α Enhancement of Experimental Metastasis”,Cancer Research, Jun. 15, 1994, vol. 54, pp. 3233-3236.
Mitsuaki Isobe et al, “Immunosuppression to Cardiac Allografts and Soluble Antigens by Anti-Vascular Cellular Adhesion Molecule-1 and Anti-Very Late Antigen-4 Monoclonal Antibodies”,The Journal of Immunology, 1994, vol. 153, pp. 5810-5818.
Yoji Shimizu et al, “Integrins in the Immune System”,Advances in Immunology, 1999, vol. 72, pp. 325-380.
Chiba Akira
Izawa Hiroyuki
Makino Shingo
Murata Masahiro
Nakanishi Eiji
Ajinomoto Co. Inc.
Jiang Shaojia A.
Krishnan Ganapathy
Oblon & Spivak, McClelland, Maier & Neustadt P.C.
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