Phenylalanine ammonia lyase-producing microbial cells

Details Phenylalanine ammonia lyase-producing microbial cells Phenylalanine ammonia lyase-producing microbial cells

1983-10-31

1987-01-13

Shapiro, Lionel M.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing alpha or beta amino acid or substituted amino acid...

4351721, 435232, 435255, 435911, C12P 1322, C12N 1500, C12N 988, C12N 116, C12R 1645

Patent

active

046364668

ABSTRACT:
This invention relates to novel microbial strains which produce phenylalanine ammonia-lyase. These novel microbial strains have the ability to grow on minimal essential media which contain, as substantially the sole carbon source, L-tyrosine. Also disclosed are methods for making phenylalanine ammonia-lyase and methods for making phenylalanine.

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Ogata, et al., "Metabolism of Aromatic Amino Acid in Microorganisms", Oct. 3, 1966, Agr. Biol. Chem. vol. 31, No. 2, pp. 200-206, (1967).
Hodgins, "Yeast Phenylalanine Ammonia-lyase", The Journal of Biological Chemistry, Issue of May 10, pp. 2977-2985 (1971).
Havir, et al., "L-Phenylalanine Ammonia-lyase. II. Mechanism and Kinetic Properties of the Enzyme from Potato Tubers", Biochemistry, vol. 7, May 1968.

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