Organic compounds -- part of the class 532-570 series – Organic compounds – Nitriles
Patent
1992-05-28
1993-09-21
Dees, Jose G.
Organic compounds -- part of the class 532-570 series
Organic compounds
Nitriles
558408, 558404, 558405, 558406, 558407, C07C25533, C07C25536, C07C25542, A61K 31275
Patent
active
052471195
ABSTRACT:
A class of substituted phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds having immunosuppressive properties is described. Compounds of this class would be useful in reducing recipient rejection of transplanted organs and for treatment of autoimmune or inflammatory diseases. Compounds of particular interest are of the formula ##STR1## wherein each of m and n is a number independently selected from one to five, inclusive; wherein R.sup.1 is selected from hydrido, alkyl, hydroxyalkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, alkenyl and alkynyl; wherein R.sup.6 is selected from loweralkyl; wherein each of R.sup.8, R.sup.9, R.sup.10 and R.sup.12 through R.sup.16 is independently selected from hydrido, hydroxy, alkyl, hydroxyalkyl, alkoxy, alkenyl, alkynyl, alkylcarbonyl, alkoxycarbonyl, alkylcarbonylalkenyl, alkylaminocarbonyl and alkoxyalkyl; or a tautomer thereof or a pharmaceutically-acceptable salt thereof.
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Farah, Jr. John M.
Fowler Kerry W.
Gregory Susan A.
McKearn John P.
Mueller Richard A.
Dees Jos,e G.
Frazier B.
G. D. Searle & Co.
Keane J. Timothy
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