Phenylacetic acid derivatives

Details Phenylacetic acid derivatives Phenylacetic acid derivatives

1975-12-30

1978-01-10

Myers, Jane S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

424263, 424267, 424278, 424317, 424324, 26029382, 260295R, 2603409R, 260520C, 260599, 560 62, C07C 6976, A61K 31215

Patent

active

040679969

ABSTRACT:
The invention provides novel phenylacetic acid derivatives of the formula: ##STR1## in which X and Y are the same or different and each represents halogen and R represents hydroxyl, alkoxy of 1 to 4 carbon atoms, a radical of formula R.sub.1 --NH--C.sub.n H.sub.2n --O--, in which n is an integer from 1 to 4 and R.sub.1 is hydrogen or an alkanoyl radical R.sub.2 CO--, in which R.sub.2 is alkyl of 1 to 4 carbon atoms, a radical of formula R.sub.4 NH--, in which R.sub.4 is hydrogen or --C.sub.m H.sub.2m OH, where m is an integer from 1 to 3, or a radical of formula: ##STR2## --OC.sub.m H.sub.2m --COOR.sub.2 or --O(CH.sub.2).sub.p --Z radical, where n, m and R.sub.2 have the meanings given above, p is 0 or 1, and Z is a saturated or unsaturated ring with 6 ring atoms, one of which can be nitrogen, and which can carry from 1 to 3 methyl radicals, and the addition salts which such a derivative which contains a salifiable basic group forms with pharmaceutically acceptable acids and a process for their preparation. These compounds are useful as hypolipaemic and hypocholesterolaemic agents.

REFERENCES:
patent: 3517050 (1970-06-01), Bolhofer
patent: 3517051 (1970-06-01), Bolhofer

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