Phenylacetate derivatives or pharmaceutically acceptable...

Details Phenylacetate derivatives or pharmaceutically acceptable... Phenylacetate derivatives or pharmaceutically acceptable...

2011-05-10

2011-05-10

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

07939672

ABSTRACT:
Disclosed herein are a new phenylacetate derivative represented by Chemical Formula 1 or pharmaceutically acceptable salt thereof, a preparation method thereof, and a composition for prevention or treatment of diseases induced by the activation of T-type calcium ion channels containing the same. The composition containing the phenylacetate derivative according to the present invention effectively inhibits the activation of T-type calcium ion channels and may be useful in the prevention or treatment of diseases such as hypertension, cancer, epilepsy, and neurogenic pains induced by the activation of T-type calcium ion channels.wherein, X, R1, and R3are as defined herein.

REFERENCES:
patent: 10-0743255 (2007-07-01), None
patent: 10-0754325 (2007-08-01), None
patent: 10-0784195 (2007-12-01), None
Lee, et al., Synthesis and Evaluation of α,α′-disubstituted Phenylacetate Derivatives for T-type Calcium Channel Blockers, Bioorganic & Medicinal Chemistry Letters, 18, 4424-4427 (2008); included in IDS.
Khosravani, et al., “Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy”, Annals of Neurology, 2005, 57(5):745-749.
Vitko, et al., “Functional characterization and neuronal modeling of the effects of childhood absence epilepsy variants of CACNA1H, a T-type calcium channel”, The Journal of Neuroscience, 2005, 25(19):4844-4855.
Barton, et al., “The antihyperalgesic effects of the T-type calcium channel blockers ethosuximide, trimethadione, and mibefradil”, European Journal of Pharmacology, 2005, 521(1-3):79-85.
Berridge, et al., “Calcium signalling: Dynamics, homeostasis and remodelling”, Nature Reviews: Molecular Cell Biology, 2003, 4:517-529.
Lee, et al., “Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers”, Bioorganic & Medicinal Chemistry Letters, 2008, 18:4424-4427.

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