Phenylacetamides suitable as protein kinase inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C514S303000, C544S362000, C546S118000

Reexamination Certificate

active

08030311

ABSTRACT:
The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

REFERENCES:
patent: 5180724 (1993-01-01), Bowles et al.
patent: 5359073 (1994-10-01), Weier et al.
patent: 2004/0019046 (2004-01-01), Pevarello et al.
patent: 2010/0075980 (2010-03-01), Furet et al.
patent: WO 91/17162 (1991-11-01), None
patent: WO 02/48114 (2002-06-01), None
patent: WO 02/48411 (2002-06-01), None
patent: WO 03/099820 (2003-12-01), None
patent: WO 2005/021531 (2005-03-01), None
patent: WO 2006/108640 (2006-10-01), None
patent: WO 2008/046802 (2008-04-01), None
Pevarello et al; “3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization”; Journal of Medicinal Chemistry 48:2944-2956 (2005).

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