Phenylacetamides being FLT3 inhibitors

Details Phenylacetamides being FLT3 inhibitors Phenylacetamides being FLT3 inhibitors

2011-07-12

2011-07-12

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S303000, C544S362000, C546S118000

Reexamination Certificate

active

07977338

ABSTRACT:
Compounds of formulawherein the residues R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, salts thereof; their use, methods of their use, processes for their production, pharmaceutical compositions comprising them, their combinations with second drug substances and the use thereof and the like. The compounds are protein kinase inhibitors and can be used for the treatment of diseases mediated by protein kinase inhibitors, e.g. for the treatment of various proliferative diseases.

REFERENCES:
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patent: 5359073 (1994-10-01), Weier et al.
patent: 2004/0019046 (2004-01-01), Pevarello et al.
patent: 2008/0319005 (2008-12-01), Bold et al.
patent: WO 91/17162 (1991-11-01), None
patent: WO 02/48114 (2002-06-01), None
patent: WO 03/099820 (2003-12-01), None
patent: 2005/021531 (2005-03-01), None
patent: 2006/108640 (2006-10-01), None
patent: WO 2008/046802 (2008-04-01), None
Pevarello et al; “3-Aminopyrazole Inhibitors of CDK2/Cyclin A as Antitumor Agents. 2. Lead Optimization”; Journal of Medicinal Chemistry 48:2944-2956 (2005).

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