Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1978-01-26
1980-07-15
Lee, Mary C.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
260239A, 26032636, 2603264, 2603407, 2603409R, 260349, 260559A, 260559R, 424244, 424278, 424320, C07D40504, A61K 3140, C07D20704
Patent
active
042128781
ABSTRACT:
N-[(1-Amino-4-(mono or di-oxygen-group-substituted)cyclohex-1-yl)methyl]phenylacetamide derivatives of the formula 1 ##STR1## wherein R, R.sub.1, R.sub.2, R.sub.3, P, Q, X and Y are defined in the specification, e.g., 2-(3,4-dichlorophenyl)-N-[[8-(1-pyrrolidinyl)-1,4-dioxaspiro[4.5]dec.-8-yl ]methyl]acetamide, and their pharmacologically acceptable salts, have analgesic drug properties with lower physical dependence liability characteristics than morphine or methadone, for use as analgesic drugs in mammalian animals including humans.
REFERENCES:
patent: 3975443 (1976-08-01), Harper et al.
patent: 4049663 (1977-09-01), Harper
patent: 4065573 (1977-12-01), Lednicer
patent: 4098904 (1978-07-01), Szmuszkovicz
patent: 4152459 (1979-05-01), Szmuszkovicz
patent: 4156733 (1979-05-01), Szmuszkovicz
Harper et al.; J. Med. Chem. vol. 17, pp. 1188-1193 (1974).
Buttain et al.; But. Pharm. Soc. Proceeding pp. 158p-159p (1973).
Lednicer Daniel
Szmuszkovicz Jacob
Lee Mary C.
Reynolds John T.
The Upjohn Company
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