Phenyl-substituted tricyclic antibacterial agent intermediates

Details Phenyl-substituted tricyclic antibacterial agent intermediates Phenyl-substituted tricyclic antibacterial agent intermediates

1984-01-26

1986-07-29

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

544353, 546165, 546166, C07D21504, C07D21512, C07D24142, C07D26536

Patent

active

046031995

ABSTRACT:
Antimicrobial compounds of the following formula are disclosed: ##STR1## wherein X is selected from the group consisting of --O--, --CH.sub.2 and ##STR2## m is 0 or 1; R.sub.1 is selected from the group consisting of hydrogen, nitro, amino, lower alkyl, lower alkanamido, lower N,N-dialkylamino, formamido, hydroxy, lower alkoxy, halogen, lower haloalkanamido and pyrryl; n is 1 or 2; and R.sub.2 is selected from the group consisting of hydrogen, methyl, fluoro, chloro and nitro. Acyl chlorides, esters, alkylaminoalkyl ester salts, amides and pharmaceutically acceptable carboxylate salts are also disclosed. Pharmaceutical compositions containing these compounds, methods of using these compound and synthetic intermediates are also disclosed.

REFERENCES:
patent: 4348521 (1982-09-01), Gerster

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