Phenyl substituted carboxylic acids

Details Phenyl substituted carboxylic acids Phenyl substituted carboxylic acids

2005-11-18

2008-12-16

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

C549S048000, C549S461000, C514S443000, C514S468000

Reexamination Certificate

active

07465825

ABSTRACT:
Disclosed are compounds and pharmaceutically acceptable salts of formula (A):which are useful in the treatment of metabolic disorders related to insulin resistance, leptin resistance, or hyperglycemia. Compounds of the invention include inhibitors of Protein tyrosine phosphatases, in particular Protein tyrosine phosphatase-1B (PTP-1B), that are useful in the treatment of diabetes and other PTP mediated diseases, such as cancer, neurodegenerative diseases and the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.

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Breslin et al. Bioorganic & Medicinal Chemistry Letters (1998), 8(23),3311-3316.
Argade et al. Journal of Medicinal Chemistry, 1998, 41, 3337-3346.

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