Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Nitrogen containing other than solely as a nitrogen in an...
Patent
1997-08-20
1999-12-21
O'Sullivan, Peter G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Nitrogen containing other than solely as a nitrogen in an...
514346, 514821, 514866, 514921, 546291, 564153, 564154, 564155, 564156, A61K 31165
Patent
active
060050101
ABSTRACT:
Compounds of the formula ##STR1## where T is ##STR2## and R(A), R(B), R(C), R(D), R(E), R(F), x and y have the meanings indicated in the claims, and their pharmaceutically acceptable salts are effective inhibitors of the cellular sodium-proton antiporter (Na.sup.+ /H.sup.+ exchanger). These compounds are therefore outstandingly suitable for treatment of all illnesses which are to be attributed to increased Na.sup.+ /H.sup.+ exchange.
REFERENCES:
patent: 4544670 (1985-10-01), Studt et al.
Duff et al.; "Amiloride: Antiarrhythmic and Electrophysiologic Actions in Patients with Inducible Sustained Ventricular Tachycardia", Circulation, vol. 79, No. 6, pp. 1257-1263, Jun. 1989.
A. Schomig et al.; "Inhibition of Na.sup.+ /H.sup.+ Exchange Suppresses Noradrenaline Release and Arrhythmias in the Ischemic Rat Heart", Eur. Heart J. 9(suppl. 1) p. 167 (1988), Book of Abstracts.
Derwent Abstract of EP 640 587.
Derwent Abstract of DE 44 21 536.
Brendel Joachim
Jansen Hans-Willi
Kleemann Heinz-Werner
Lang Hans Jochen
Scholz Wolfgang
Hoechst Aktiengesellschaft
O'Sullivan Peter G.
LandOfFree
Phenyl-substituted alkenylcarboxylic acid guanidides, process fo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Phenyl-substituted alkenylcarboxylic acid guanidides, process fo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenyl-substituted alkenylcarboxylic acid guanidides, process fo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-505777