Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-10-22
1999-03-02
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514381, 514465, 548127, 548128, 548134, 548136, 548250, 548253, 548255, 5482622, 548950, 549345, A61K 3136, C07D28504, C07D30794, C07D31196
Patent
active
058771913
ABSTRACT:
The present invention is directed to certain novel compounds represented by structural formula I: ##STR1## or a pharmaceutically acceptable salt thereof, wherein R.sup.3, R.sup.6, R.sup.7, R.sup.8, R.sup.11, R.sup.12, R.sup.13, m, n and the dashed lines are defined herein. The invention is also concerned with pharmaceutical formulations comprising these novel compounds as active ingredients and the use of the novel compounds and their formulations in the treatment of certain disorders. The compounds of this invention are tachykinin receptor antagonists and are useful in the treatment of inflammatory diseases, pain or migraine, asthma and emesis.
REFERENCES:
patent: 5387595 (1995-02-01), Mills et al.
patent: 5688806 (1997-11-01), Desai et al.
Caldwell Charles G.
Chiang Yuan-Ching
Dorn Conrad
Finke Paul
Hale Jeffrey
Merck & Co. , Inc.
Richter Johann
Rose David L.
Solola Taofiq A.
Thies J. Eric
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