Phenyl pyrrolidine ether tachykinin receptor antagonists

Details Phenyl pyrrolidine ether tachykinin receptor antagonists Phenyl pyrrolidine ether tachykinin receptor antagonists

2004-09-24

2008-12-23

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S224000, C544S242000, C548S300100, C548S400000, C548S215000, C548S356100, C546S249000, C546S250000, C546S255000, C549S029000, C549S200000, C549S429000, C514S247000, C514S277000, C514S359000, C514S430000, C514S438000, C514S449000, C514S235500, C514S249000, C514S254010, C514S326000

Reexamination Certificate

active

07468437

ABSTRACT:
The present invention is directed to certain phenyl pyrrolidine ether compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, depression, and anxiety.

REFERENCES:
patent: 6166037 (2000-12-01), Budhu et al.
patent: 6458787 (2002-10-01), Martins et al.
patent: 1 386 912 (2004-04-01), None
Hale, et al. “1,3,4-Trisubstituted pyrrolidine CCR5 Receptor Antagonists. Part 1: Discovery of the Pyrrolidine Scaffold and Determination of Its Stereochemical Requirements”, Bioorganic & Medicinal Chemistry Letters, vol. 11, pp. 1437-1440 (2001).
DeVane, “Substance P: A New Era, a New Role”, Pharmacotherapy, vol. 21(9), pp. 1061-1069 (2001).
Lowe, “The Painful History of Substance P”, Corante, Aug. 25, 2005.
Ebner, et al. “The role of substance P in stress and anxiety responses”, Amino Acids, vol. 31, pp. 251-272 (2006).

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