Phenyl-piperazine derivatives as serotonin reuptake inhibitors

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C546S236000, C546S339000, C544S395000, C540S575000, C540S611000, C514S212010, C514S218000, C514S255030, C514S277000

Reexamination Certificate

active

07148238

ABSTRACT:
The invention provides compounds represented by the general formula Iwherein the substituents are defined in the application. The compounds are useful in the treatment of an affective disorder, including depression, anxiety disorders including general anxiety disorder and panic disorder and obsessive compulsive disorder.

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Lawrence L. Martin, et al. “Synthesis of Spiro[isobenzofur4an-1(3 H), 4′-piperidines] as Potential Central Nervous Systems Agents, 5. Conformationally Mobile Analogues Derived by Furan Ring Opening”, Journal of Medicinal Chemistry, 1979, vol. 22, No. 11.

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