Phenyl glyoxamides as SPLA2 inhibitors

Details Phenyl glyoxamides as SPLA2 inhibitors Phenyl glyoxamides as SPLA2 inhibitors

1997-11-24

1999-06-29

Pak, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Radical -xh acid, or anhydride, acid halide or salt thereof...

514114, 514119, 514506, 514517, 514538, 514539, 514541, 514561, 514562, 514567, 514576, 514618, 514621, 514622, 558 49, 558 50, 558 60, 558169, 558170, 558174, 560 9, 560 36, 560 37, 560 42, 562 15, 562 42, 562426, 562441, 562442, 562451, 562455, 562456, 564162, 564169, 564171, A61K 31165, A61K 31055, A61K 3119, A61K 31255, C07C22900, C07C30924, C07C23300, C07F 938

Patent

active

059169222

ABSTRACT:
A class of novel phenyl glyoxamides is disclosed together with the use of such compounds for inhibiting sPLA.sub.2 mediated release of fatty acids for treatment of conditions such as septic shock.

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patent: 5344843 (1994-09-01), Guthrie et al.
patent: 5352690 (1994-10-01), Sofia
Geffken, D. et al., "An Improved Synthesis of N-Alkoxy-.alpha.-oxo-Arylacetamides", Synthetic Communications, vol. 26(22), pp. 4153-4156, 1996.
Ozawa, F. et al., "Palladium-Catalyzed Double Carbonylation of Aryl Halides to give .alpha.-Keto Amides. Mechanical Studies." J. Am. Chem. Soc., vol. 107, pp. 3235-3245, 1985.
Chemical Abstracts 113:114766m, 1990.
Chemical Abstracts 122:239485, 1995.

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