Phenyl-furan compounds as vitamin D receptor modulators

Details Phenyl-furan compounds as vitamin D receptor modulators Phenyl-furan compounds as vitamin D receptor modulators

2004-11-16

2008-12-23

Seaman, D. Margaret (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C514S471000

Reexamination Certificate

active

07468449

ABSTRACT:
The present invention relates to novel, non-secosteroidal, phenyl-furan compounds with vitamin D receptor (VDR) modulating activity that are less hypercalcemic than 1α,25dihydroxy vitamin D3. These compounds are useful for treating bone disease and psoriasis.

REFERENCES:
patent: 4282246 (1981-08-01), Holland
patent: 6218430 (2001-04-01), Allegretto et al.
patent: 2006/0094778 (2006-05-01), Nagpal et al.
patent: 2006/0135484 (2006-06-01), Nagpal et al
patent: 2006/0287536 (2006-12-01), Dahnke et al.
patent: 2006/0293385 (2006-12-01), Gajewski et al.
patent: 2007/0105951 (2007-05-01), Gajewski et al.
patent: 2007/0106095 (2007-05-01), Lu et al.
patent: 2007/0149810 (2007-06-01), Lu et al.
patent: WO 2005/051893 (2005-06-01), None
Masahiko Inouye, Toshiyuki Miyake, Masaru Furusyo, Hiroyuki Nakazumi: “Molecular recognition of beta-Ribofuranosides by synthetic polypyridine—macrocyclic receptors” J.Am. Chem. Soc. vol. 117, 1995, pp. 12416-12425, XP001206518.
Ping Huang, John Ramphal, James Wei, Congxin Liang, Bahija Jallal, Gerald McMahon and Cho Tang: “Structure-based design and discovery of novel inhibitors of protein tyrosine phosphatases” Bioorganic & Medicinal Chemistry, vol. 11, 2003, pp. 1835-1849, XP001206517.
Boehm, M., “Novel Nonsecosteroidal Vitamin D Mimics Exert VDR-modulating Activities”Chemistry&Biology, 1999, 265-275, vol. 6(5).
Nagpal, S. et al. “Vitamin D Analogs: Mechanism of Action of Therapeutic Applications”,Curr. Med. Chem. 2001, 1661-1679, vol. 8.
Bouillon R., et al. Endocrine Rev. 1995, 200-257, vol. 16.
Swann et al. “Rational Design of Vitamin D3 Analogues Which Selectively Restore Activity to a Vitamin D Receptor Mutant Associated with Rickets”Org. Lett. 2002, p. 1863-3866 vol. 4.
Swann et al. “Structure-Based Design of Selective Agonists for a Rickets-Associated Mutant of the Vitamin D Receptor”J. Am. Chem. Soc. 2002 13795-13805, vol. 124.

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