Phenyl ethers

Details Phenyl ethers Phenyl ethers

1986-07-28

1988-09-20

Reamer, James H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514567, 514619, 514652, 560 42, 562451, 564165, 564349, 564351, 2605011, A61K 31235, C07C 69736

Patent

active

047726318

ABSTRACT:
The invention concerns a series of novel phenoxyacetic acid ethers (and pharmaceutically acceptable salts thereof) of the formula I in which R.sup.1 is H or F, R.sup.2 and R.sup.3 are H or (1-3C)alkyl, Z is CH.sub.2 OH or a group --CO.R.sup.4 in which R.sup.4 is OH, NH.sub.2 or (1-6C)alkoxy. The invention also includes pharmaceutical compositions for use in treating obesity and related conditions and provides processes for the manufacture of the novel ethers.

REFERENCES:
patent: 3723524 (1973-03-01), Augstein et al.
patent: 3873600 (1975-03-01), Brandstrom et al.
patent: 4146638 (1979-03-01), Renth et al.
patent: 4191765 (1980-03-01), Fritsch et al.
patent: 4329358 (1982-05-01), Ainsworth et al.
patent: 4338333 (1982-07-01), Ainsworth et al.
Carlsson et al I, Chemical Abstracts, vol. 98, No. 106954c (1983).
Carlsson et al II, Chemical Abstracts, vol. 98, No. 137626b (1983).
Carlsson et al III, Chemical Abstracts, vol. 89, No. 129247c (1978).
Ainsworth et al, Chemical Abstracts, vol. 104, No. 224720p (1986).
Duckworth et al, Chemical Abstracts, vol. 104, No. 224722r (1986).

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