Phenyl butanones

Details Phenyl butanones Phenyl butanones

1975-06-20

1977-12-13

Thomas, Jr., James O.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

560140, 560144, 260590D, 260590R, 260592, 260621R, 260607A, 260571, 260569, 260609R, 260618R, 260618D, 424308, 424309, 424305, 424325, 424339, 424340, 424343, 424335, C07C 4976, C07C 4984, A01N 924

Patent

active

040629783

ABSTRACT:
Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO, an oxygen atom or a direct bond; the dotted line represents a double bond which is optionally present when Y is an oxygen atom or a direct bond; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R.sub.3 is alkyl of 3-8 carbon atoms, cycloalkyl of 3-8 carbon atoms, alkenyl of 3-8 carbon atoms, cycloalkenyl of 5-8 carbon atoms, phenyl or phenyl substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloxyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino.
Compounds of the above formula are novel except that R.sub.1 must be methyl: when R.sub.3 -- Y is a 4-phenyl group, R.sub.2 is hydrogen and X is CO; when R.sub.3 -- Y is a 4-benzyl group and R.sub.2 is hydrogen; and also when R.sub.3 -- Y is a 3-benzoyl group, R.sub.2 is hydrogen and X is CO.

REFERENCES:
patent: 2245147 (1941-06-01), John et al.
patent: 3420853 (1969-01-01), Moed et al.
patent: 3458565 (1969-07-01), Bicking et al.
patent: 3646114 (1972-02-01), Pitt
patent: 3879449 (1975-04-01), Anderson et al.
Johnson et al., J. Chem. & Eng. Data, vol. 16, No. 1, pp. 112-115 (1971).
Sylvestre; Julia et al., C. R. Acad. Sc. Paris, Series C, t270 pp. 1308-1311 (1970).

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