Phenyl benzothiophene hypolipidemic derivatives

Details Phenyl benzothiophene hypolipidemic derivatives Phenyl benzothiophene hypolipidemic derivatives

1988-11-08

1990-08-28

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

549 44, 549 51, C07D40902, C07D33350

Patent

active

049526022

ABSTRACT:
Biphenyl derivative of the formula: ##STR1## wherein R.sup.1 is hydrogen atom or a lower alkoxycarbonyl group and R.sup.2 is a lower alkoxycarbonyl group, or R.sup.1 and R.sup.2 are combined together to form a group of the formula: each of R.sup.3 and R.sup.4 is a lower alkoxy group; and Ring A is a substituted or unsubstituted sulfur-containing or nitrogen-containing heterocyclic ring, with the claims being drawn to Ring A as thiophene and a pharmaceutically acceptable salt thereof are disclosed. Said biphenyl derivative (I) and its salt have excellent hypolipidemic activity and are useful for treatment or prophylaxis of hyperlipidemia and/or arterioscelerosis.

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