Phenyl and benzoyl substituted imidazo-fused heterocyclic calciu

Details Phenyl and benzoyl substituted imidazo-fused heterocyclic calciu Phenyl and benzoyl substituted imidazo-fused heterocyclic calciu

1987-09-21

1989-11-14

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548154, 548151, 548126, 544184, 544281, 544330, 544350, 568337, 514243, 514249, 514258, 514363, 514366, A61K 31425, C07D51304, C07D48704

Patent

active

048808245

ABSTRACT:
Heterocyclic compounds of formulae (I) and (II): ##STR1## where R.sup.1 and R.sup.2 are alkyl, R.sup.3 is H or alkyl, m is 2-5 and Het is a hetercycle such as thiazole, benzothiazole, substituted benzothiazole, pyrazine, triazine, thiadiazole, substituted thiadiazole, pyrimidine or substituted pyrimidine. The compounds are calcium channel blockers useful in the treatment of cardiovascular conditions such as hypertension or angina.

REFERENCES:
patent: 4103012 (1978-07-01), Gubin et al.
patent: 4386092 (1983-05-01), Oe et al.
patent: 4727145 (1988-02-01), Press et al.
Abstract for WO84/167332 (1984).
Yoshitomi Pharmaceutical, Chemical Abstract, vol. 101, No. 151851h (1984).
Burger, Medicinal Chemistry, pp. 72-75 (1960).

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