Phenyl amidine lactones useful as platelet aggregation inhibitor

Details Phenyl amidine lactones useful as platelet aggregation inhibitor Phenyl amidine lactones useful as platelet aggregation inhibitor

1995-05-26

1997-03-18

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514444, 514460, 514422, 5462821, 549 60, 549293, 548517, C07D40506, A61K 3144

Patent

active

056123558

ABSTRACT:
This invention relates to phenyl amidine alkanoic acids and lactones having the following formula ##STR1## or a pharmaceutically acceptable salt which are useful in the inhibition of platelet aggregation. This invention also relates to pharmaceutical compositions of such phenyl amidine derivatives.

REFERENCES:
patent: 4517686 (1985-05-01), Ruoslahti et al.
patent: 4578079 (1986-03-01), Ruoslahti et al.
patent: 4589881 (1986-05-01), Pierschbacher et al.
patent: 4614517 (1986-09-01), Ruoslahti et al.
patent: 4661111 (1987-04-01), Ruoslahti et al.
patent: 4683291 (1987-07-01), Zimmerman et al.
patent: 4791102 (1988-12-01), Bernat et al.
patent: 4857508 (1989-08-01), Adams et al.
patent: 4879313 (1989-11-01), Tjoeng et al.
patent: 4977168 (1990-12-01), Bernat et al.
patent: 5220050 (1993-06-01), Bovy et al.
M. Kloczewiak et al. "Platelet Receptor Recognition site on Human Fibrinogen" Biochemistry, 23(8), pp. 1767-1774. Jan. 1984.
Z. Ruggeri et al. "Inhibition of platelet function with synthetic pepitides designed to be high-affinity antagonists of fibrinogen binding to platelets" Proc. Natl. Acad. Sci., USA. 83, pp. 5708-5712. Aug. 1986.
E. Plow et al. "The Effect of ARG-GLY-ASP-containing peptides on fibrinogen and von Willebrand factor binding to platelets" Proc. Natl. Acad. Sci., USA. 82, pp. 8057-8061. Dec. 12, 1985.
D. Haverstick et al. "Inhibition of Platelet Adhesion to Fibronectin, Fibrinogen, and von Willebrand Factor Substrates by a Synthetic Tetrapeptide Derived From the Cell-Binding Domain of Fibronectin", Blood 66(4), pp. 946-952. Oct. 1985.
E. Ruoslahti et al. "New Perspectives in Cell Adhesion: RGD and Integrins" Science. 23, pp. 491-497. Oct. 1987.
P. Walsmann et al. "Synthetic Inhibitors of Serine Proteinases" Pharmazie. 29(5), pp. 333-336. Jan. 1974.

Affiliated with

Also associated with

Rating

Phenyl amidine lactones useful as platelet aggregation inhibitor does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Phenyl amidine lactones useful as platelet aggregation inhibitor, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Phenyl amidine lactones useful as platelet aggregation inhibitor will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1706610