Phenoxypropionic acid derivatives and pharmaceutical preparation

Details Phenoxypropionic acid derivatives and pharmaceutical preparation Phenoxypropionic acid derivatives and pharmaceutical preparation

1975-12-24

1977-08-02

Turner, V. D.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

260559B, A61K 31165, C07C10375

Patent

active

040396835

ABSTRACT:
Phenoxypropionic acid derivatives of the formula ##STR1## wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O--alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##STR2## with a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.

REFERENCES:
patent: 3262850 (1966-07-01), Jones et al.
patent: 3712927 (1973-01-01), Howe et al.

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