Phenoxypropionic acid derivatives

Details Phenoxypropionic acid derivatives Phenoxypropionic acid derivatives

1974-08-14

1976-07-06

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029381, 260465F, 260520C, 260544D, 260558H, 260559D, 260613R, 424267, 424308, 424317, 424324, C07C 6976

Patent

active

039681432

ABSTRACT:
Phenoxypropionic acid derivatives of the formula ##SPC1##
Wherein Q is H or a halogen atom, R is H or CH.sub.3, Z is --OH, --O-alkyl of 1-4 carbon atoms, 1-methyl-4-piperidyloxy, or --NHCH.sub.2 CH.sub.2 OH, and the physiologically acceptable salts thereof; possess cholesterol and triglyceride blood-level lowering activity and can be prepared, e.g., by reaction of a phenol of the formula ##SPC2##
With a compound of the formula X--CR(CH.sub.3)--CO--Z wherein X is Cl, Br, I, or a free or esterified OH-group, and Q, R and Z have the values given above.

REFERENCES:
patent: 3262850 (1966-07-01), Jones et al.
patent: 3586709 (1971-06-01), Richter et al.
Burger, "Medicinal Chemistry", Wiley Interscience, N.Y. (1970), pp. 71-72.

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